Article
The association of the Thr715Pro P-selectin genotype with levels of P-selectin in platelet concentrates.
Vox sanguinis - 1 Nov 2014
Jilma-Stohlawetz P, Mannhalter C, Kaider A, Waidacher T, Jilma B, Panzer S
Abstract excerpt
BACKGROUND AND OBJECTIVES: P-selectin is stored in the alpha granules of platelets and in the Weibel Palade bodies of endothelial cells; upon activation, it is translocated to the cell surface and released into the plasma in soluble form. One variant of the P-selectin gene, the Thr715Pro polymorphism, is strongly associated with the plasma levels of soluble P-selectin. In platelet concentrates soluble P-selectin...
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