The Thr715Pro variant impairs terminal glycosylation of P-selectin.

doi:10.1160/TH12-01-0047

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Article

The Thr715Pro variant impairs terminal glycosylation of P-selectin.

Thrombosis and haemostasis - 1 Nov 2012

Subramanian Hariharan, Gambaryan Stepan, Panzer Simon, Gremmel Thomas, Walter Ulrich, Mannhalter Christine

Abstract excerpt

P-selectin variant 715Pro is associated with lower concentrations of plasma P-selectin and reduced risk for thrombosis. We examined the influence of 715Pro on P-selectin synthesis, post-translational processing, surface expression and function using HEK293 cells, which do not express endogenous P-selectin. Mass spectrometry revealed that HEK293 cells produced recombinant P-selectin which has a glycosylation...

Topics

Amino Acid Sequence
Amino Acid Substitution
Base Sequence
Blood Platelets
Cell Adhesion
Cell Membrane
Genetic Variation
Glycosylation
Golgi Apparatus
HEK293 Cells
HL-60 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Monocytes

Mutagenesis, Site-Directed

P-Selectin

Protein Processing, Post-Translational

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23014585
DOI: 10.1160/TH12-01-0047
PMCID: PMC6176910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23014585-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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