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Article

The Thr715Pro variant impairs terminal glycosylation of P-selectin.

Thrombosis and haemostasis - 1 Nov 2012

Subramanian Hariharan, Gambaryan Stepan, Panzer Simon, Gremmel Thomas, Walter Ulrich, Mannhalter Christine

Abstract excerpt

P-selectin variant 715Pro is associated with lower concentrations of plasma P-selectin and reduced risk for thrombosis. We examined the influence of 715Pro on P-selectin synthesis, post-translational processing, surface expression and function using HEK293 cells, which do not express endogenous P-selectin. Mass spectrometry revealed that HEK293 cells produced recombinant P-selectin which has a glycosylation...

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Identifiers

PMID: 23014585
DOI: 10.1160/TH12-01-0047
PMCID: PMC6176910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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