Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.

Breast cancer research : BCR - 1 Jan 2005

Shatalova Ekaterina G, Walther Susan E, Favorova Olga O, Rebbeck Timothy R, Blanchard Rebecca L

Abstract excerpt

INTRODUCTION: Estrogens are important in breast cancer development. SULT1A1 and UGT1A1 catalyze estrogen metabolism and are polymorphic. The SULT1A1*2 protein exhibits low activity, and a TA repeat within the UGT1A1 promoter alters the level of expression of the protein. We hypothesized that the SULT1A1*2 allozyme has decreased capacity to sulfate estrogens, that the SULT1A1*2 allele conferred increased capacity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylsulfotransferase
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogens

Share to Ethnicity

Share to Glucuronosyltransferase

Share to Odds Ratio

Share to Prognosis

Share to Receptors, Estrogen

Source

Open in PubMed Open full text

Identifiers

PMID: 16280036
DOI: 10.1186/bcr1318
PMCID: PMC1410736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.PMID 16280036Read ↗

[Association of polymorphisms in SULT1A1 and UGT1A1 Genes with breast cancer risk and phenotypes in Russian women].Semantic proximity Read ↗

Sulfotransferase genetic variation: from cancer risk to treatment response.Semantic proximity Read ↗

UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients.Semantic proximity Read ↗

CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer.Semantic proximity Read ↗

Human SULT1A1 gene: copy number differences and functional implications.Semantic proximity Read ↗

Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics.Semantic proximity Read ↗

Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.Semantic proximity Read ↗

CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.Semantic proximity Read ↗

Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?Semantic proximity Read ↗

Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics.Semantic proximity Read ↗

Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies.Semantic proximity Read ↗

Relationship of SULT1A1 copy number variation with estrogen metabolism and human health.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.