Article
Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics.
The Journal of pharmacology and experimental therapeutics - 1 Aug 2007
Ji Yuan, Moon Irene, Zlatkovic Jelena, Salavaggione Oreste E, Thomae Bianca A, Eckloff Bruce W, Wieben Eric D, Schaid Daniel J, Weinshilboum Richard M
Abstract excerpt
The human hydroxysteroid sulfotransferase (SULT) 2B1 gene is a member of the cytosolic SULT gene superfamily. The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by a single gene as a result of alternative transcription initiation and alternative splicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormones and cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolone...
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