Article
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.
Cancer - 1 May 2008
Hirata Hiroshi, Hinoda Yuji, Okayama Naoko, Suehiro Yutaka, Kawamoto Ken, Kikuno Nobuyuki, Rabban Joseph T, Chen Lee May, Dahiya Rajvir
Abstract excerpt
BACKGROUND: In estrogen biosynthetic pathways, many enzymes are important for metabolism, detoxification, and bioavailability. Polymorphisms in these genes may have an effect on the enzymes' function. For example, higher expression and activation of biosynthetic enzymes and lower expression and activation of conjugation enzymes may lead to high toxicity or carcinogenesis. The authors hypothesized that single...
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