Article
CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer.
Breast cancer (Tokyo, Japan) - 1 Jan 2004
Chacko Priya, Rajan Balakrishnan, Mathew Beela Sarah, Joseph Thomas, Pillai M Radhakrishnai
Abstract excerpt
BACKGROUND: Breast cancer is the most common cancer among women worldwide. Life-time exposure to steroid hormones, especially estrogen, is a major risk factor for breast cancer. Functional polymorphisms in genes encoding steroid metabolizing enzymes may thus be important as biomarkers of individual susceptibility to breast cancer. The CYP17 and SULT1A1 genes encode for two enzymes involved in hormone biosynthesis...
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