Article
Sulfotransferase genetic variation: from cancer risk to treatment response.
Drug metabolism reviews - 1 Nov 2013
Daniels Jaclyn, Kadlubar Susan
Abstract excerpt
Cytosolic sulfotransferases (SULTs) are phase II detoxification enzymes that are involved in the biotransformation of a wide variety of structurally diverse endo- and xenobiotics. Single-nucleotide polymorphisms (SNPs) in SULTs can alter the phenotype of the translated proteins. SNPs in some SULTs are fairly uncommon in the population, but some, most notably for SULT isoform 1A1, are commonly found and have been...
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