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Article

Relationship of SULT1A1 copy number variation with estrogen metabolism and human health.

The Journal of steroid biochemistry and molecular biology - 1 Nov 2017

Liu Jixia, Zhao Ran, Ye Zhan, Frey Alexander J, Schriver Emily R, Snyder Nathaniel W, Hebbring Scott J

Abstract excerpt

Human cytosolic sulfotransferase 1A1 (SULT1A1) is considered to be one of the most important SULT isoforms for metabolism, detoxification, and carcinogenesis. This theory is driven by observations that SULT1A1 is widely expressed in multiple tissues and acts on a wide range of phenolic substrates. SULT1A1 is subject to functional common copy number variation (CNV) including deletions or duplications. However, it...

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Identifiers

PMID: 28867356
DOI: 10.1016/j.jsbmb.2017.08.017
PMCID: PMC5675753

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