Article
Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2010
Yong Mellissa, Schwartz Stephen M, Atkinson Charlotte, Makar Karen W, Thomas Sushma S, Newton Katherine M, Aiello Bowles Erin J, Holt Victoria L, Leisenring Wendy M, Lampe Johanna W
Abstract excerpt
OBJECTIVE: Sex hormones are metabolized to less active compounds via (a) glucuronidation catalyzed by UDP-glucuronosyltransferases (UGT) and (b) sulfation catalyzed by sulfotransferases (SULT). Functional UGT and SULT polymorphisms can affect clearance of sex hormones, thereby influencing exposure in hormone-sensitive tissues, such as the breast. We assessed relationships between functional polymorphisms in the...
Topics
- Adult
- Breast
- Female
- Genetic Predisposition to Disease
- Glucuronosyltransferase
- Humans
- Mammography
- Middle Aged
- Polymorphism, Single Nucleotide