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Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.

Molecular microbiology - 1 Nov 2005

Urano Jun, Comiso Melissa J, Guo Lea, Aspuria Paul-Joseph, Deniskin Roman, Tabancay Angel P, Kato-Stankiewicz Juran, Tamanoi Fuyuhiko

Abstract excerpt

Rheb GTPase is a key player in the control of growth, cell cycle and nutrient uptake that is conserved from yeast to humans. To further our understanding of the Rheb pathway, we sought to identify hyperactivating mutations in the Schizosaccharomyces pombe Rheb, Rhb1. Hyperactive forms of Rhb1 were found to result from single amino acid changes at valine-17, serine-21, lysine-120 or asparagine-153. Expression of...

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PMID: 16262791
DOI: 10.1111/j.1365-2958.2005.04877.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.PMID 16262791Read ↗

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