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Article

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.

Molecular and cellular biology - 1 Sept 2004

Li Yong, Inoki Ken, Guan Kun-Liang

Abstract excerpt

Tuberous sclerosis complex (TSC) is a genetic disease caused by a mutation in either the tsc1 or tsc2 tumor suppressor gene. Recent studies have demonstrated that TSC2 displays GAP (GTPase-activating protein) activity specifically towards the small G protein Rheb and inhibits its ability to stimulate the mTOR signaling pathway. Rheb and TSC2 comprise a unique pair of GTPase and GAP, because Rheb has high basal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15340059
DOI: 10.1128/MCB.24.18.7965-7975.2004
PMCID: PMC515062

Genes

TSC2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.PMID 15340059Read ↗

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.Semantic proximity Read ↗

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Structural insights into TSC complex assembly and GAP activity on RhebSemantic proximity Read ↗

Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.Semantic proximity Read ↗

Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.Semantic proximity Read ↗

Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.Semantic proximity Read ↗

Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).Semantic proximity Read ↗

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.Semantic proximity Read ↗

An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation.Semantic proximity Read ↗

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.Semantic proximity Read ↗

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.Semantic proximity Read ↗

Rheb binds and regulates the mTOR kinase.Semantic proximity Read ↗

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