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Article

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.

The Journal of biological chemistry - 21 Jul 2006

Yan Lijun, Findlay Greg M, Jones Rebecca, Procter Julia, Cao Yunhong, Lamb Richard F

Abstract excerpt

Gain-of-function mutants of Ras and Rho family small GTPases have proven to be important tools in analyzing signaling downstream of these small GTPases. The Ras-related GTPase Rheb has emerged as a key player downstream of TSC1-2 in activating signaling to mammalian target of rapamycin (mTOR) eff...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16728407
DOI: 10.1074/jbc.C600028200

Genes

TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16728407-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.PMID 16728407Read ↗

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Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.Semantic proximity Read ↗

Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).Semantic proximity Read ↗

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The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.Semantic proximity Read ↗

Structural insights into TSC complex assembly and GAP activity on RhebSemantic proximity Read ↗

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