Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.

Cell cycle (Georgetown, Tex.) - 15 Jul 2007

Aspuria Paul-Joseph, Sato Tatsuhiro, Tamanoi Fuyuhiko

Abstract excerpt

The TSC/Rheb/TOR signaling pathway plays important roles in growth and cell cycle regulation. The main player TOR belongs to the PI3K-related protein kinase family. Recent studies utilizing fission yeast Tor2 have led to the identification of a number of amino acid changes that lead to inactivation as well as activation of TOR kinase. Also, constitutive active mutations in its upstream regulator, Rheb, have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Monomeric GTP-Binding Proteins

Share to Mutation

Share to Phosphatidylinositol 3-Kinases

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Signal Transduction

Source

Identifiers

PMID: 17637564
DOI: 10.4161/cc.6.14.4478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.PMID 17637564Read ↗

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.Semantic proximity Read ↗

Opposite Effects of Tor1 and Tor2 on Nitrogen Starvation Responses in Fission YeastSemantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.Semantic proximity Read ↗

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Semantic proximity Read ↗

Identification of TOR signaling complexes: more TORC for the cell growth engine.Semantic proximity Read ↗

Evolutionary Conservation of the Components in the TOR Signaling PathwaysSemantic proximity Read ↗

Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional SignalsSemantic proximity Read ↗

Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell GrowthSemantic proximity Read ↗

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.Semantic proximity Read ↗

Growth Control Under Stress: mTOR Regulation through the REDD1-TSC PathwaySemantic proximity Read ↗

Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.