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Article

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.

The Journal of biological chemistry - 10 Oct 2003

Tabancay Angel P, Gau Chia-Ling, Machado Iara M P, Uhlmann Erik J, Gutmann David H, Guo Lea, Tamanoi Fuyuhiko

Abstract excerpt

Rheb GTPases represent a unique family of the Ras superfamily of G-proteins. Studies on Rheb in Schizosaccharomyces pombe and Drosophila have shown that this small GTPase is essential and is involved in cell growth and cell cycle progression. The Drosophila studies also raised the possibility that Rheb is involved in the TOR/S6K signaling pathway. In this paper, we first report identification of dominant negative...

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Identifiers

PMID: 12869548
DOI: 10.1074/jbc.M306553200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.PMID 12869548Read ↗

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