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Article

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2006

Uritani Masahiro, Hidaka Hidetoshi, Hotta Yukari, Ueno Masaru, Ushimaru Takashi, Toda Takashi

Abstract excerpt

The target of rapamycin (Tor) plays a pivotal role in cell growth and metabolism. Yeast contains two related proteins, Tor1 and Tor2. In fission yeast, Tor1 is dispensable for normal growth but is involved in amino acid uptake and cell survival under various stress conditions. In contrast, Tor2 is essential for cell proliferation; however, its physiological function remains unknown. Here we characterize the roles...

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Identifiers

PMID: 17121544
DOI: 10.1111/j.1365-2443.2006.01025.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.PMID 17121544Read ↗

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Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.Semantic proximity Read ↗

Fission yeast Tor2 promotes cell growth and represses cell differentiation.Semantic proximity Read ↗

The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.Semantic proximity Read ↗

Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.Semantic proximity Read ↗

TORC1 signaling is governed by two negative regulators in fission yeast.Semantic proximity Read ↗

Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional SignalsSemantic proximity Read ↗

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Semantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.Semantic proximity Read ↗

TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast.Semantic proximity Read ↗

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