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Article

The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.

The Journal of biological chemistry - 22 Jun 2007

Long Xiaomeng, Lin Yenshou, Ortiz-Vega Sara, Busch Susann, Avruch Joseph

Abstract excerpt

The small GTPase Rheb is a positive upstream regulator of the target of rapamycin (TOR) complex 1 in mammalian cells and can bind directly to TOR complex 1. To identify the regions of the Rheb surface most critical for signaling to TOR complex 1, we created a set of 26 mutants wherein clusters of 1-5 putative solvent-exposed residues were changed to alanine, ultimately changing 65 residues distributed over the...

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Share to Guanosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17470430
DOI: 10.1074/jbc.M610736200
PMCID: PMC3205911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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