Article
Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.
Genes & development - 15 Aug 2011
Gong Rui, Li Li, Liu Yi, Wang Ping, Yang Huirong, Wang Ling, Cheng Jingdong, Guan Kun-Liang, Xu Yanhui
Abstract excerpt
The target of rapamycin (TOR) complex 1 (TORC1) is a central cell growth regulator in response to a wide array of signals. The Rag GTPases play an essential role in relaying amino acid signals to TORC1 activation through direct interaction with raptor and recruitment of the TORC1 complex to lysosomes. Here we present the crystal structure of the Gtr1p-Gtr2p complex, the Rag homologs from Saccharomyces cerevisiae,...
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