Article
BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures.
Nature neuroscience - 1 Dec 2005
Brenner Robert, Chen Qing H, Vilaythong Alex, Toney Glenn M, Noebels Jeffrey L, Aldrich Richard W
Abstract excerpt
Synaptic inhibition within the hippocampus dentate gyrus serves a 'low-pass filtering' function that protects against hyperexcitability that leads to temporal lobe seizures. Here we demonstrate that calcium-activated potassium (BK) channel accessory beta4 subunits serve as key regulators of intrinsic firing properties that contribute to the low-pass filtering function of dentate granule cells. Notably, a critical...
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