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Article

Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome.

Brain : a journal of neurology - 1 Jun 2014

Reid Christopher A, Leaw Bryan, Richards Kay L, Richardson Robert, Wimmer Verena, Yu Christiaan, Hill-Yardin Elisa L, Lerche Holger, Scheffer Ingrid E, Berkovic Samuel F, Petrou Steven

Abstract excerpt

Epileptic encephalopathies, including Dravet syndrome, are severe treatment-resistant epilepsies with developmental regression. We examined a mouse model based on a human β1 sodium channel subunit (Scn1b) mutation. Homozygous mutant mice shared phenotypic features and pharmaco-sensitivity with Dravet syndrome. Patch-clamp analysis showed that mutant subicular and layer 2/3 pyramidal neurons had increased action...

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PMID: 24747835
DOI: 10.1093/brain/awu077

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