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Article

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.

Neurobiology of disease - 1 Aug 2014

Makinson Christopher D, Tanaka Brian S, Lamar Tyra, Goldin Alan L, Escayg Andrew

Abstract excerpt

SCN1A mutations are the main cause of the epilepsy disorders Dravet syndrome (DS) and genetic epilepsy with febrile seizures plus (GEFS+). Mutations that reduce the activity of the mouse Scn8a gene, in contrast, are found to confer seizure resistance and extend the lifespan of mouse models of DS and GEFS+. To investigate the mechanism by which reduced Scn8a expression confers seizure resistance, we induced...

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Source

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Identifiers

PMID: 24704313
DOI: 10.1016/j.nbd.2014.03.014
PMCID: PMC4077284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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