Article

Complex synaptic and intrinsic interactions disrupt input/output functions in the hippocampus of <i>Scn1b</i> knockout mice

2023-04-29

Abstract excerpt

Mutations in the SCN1B gene have been linked to severe developmental epileptic encephalopathies including Dravet syndrome. Scn1b k nock o ut (KO) mice model SCN1B loss of function disorders, demonstrating seizures, developmental delays, and early death. SCN1B encodes the protein β1, an ion channel auxiliary subunit that also has roles in cell adhesion, neurite outgrowth, and gene expression. The goal of this...

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Literature Corpus work: f3bf18f7-579d-5e7a-a80c-0d31d7ba58fc
DOI: 10.1101/2023.04.29.538823

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