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Article

Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability.

Journal of neurophysiology - 1 Aug 2016

Wang Bin, Bugay Vladislav, Ling Ling, Chuang Hui-Hsui, Jaffe David B, Brenner Robert

Abstract excerpt

BK channels are large-conductance calcium- and voltage-activated potassium channels with diverse properties. Knockout of the accessory BK β4-subunit in hippocampus dentate gyrus granule neurons causes BK channels to change properties from slow-gated type II channels to fast-gated type I channels that sharpen the action potential, increase the fast afterhyperpolarization (fAHP) amplitude, and increase spike...

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Identifiers

PMID: 27146987
DOI: 10.1152/jn.00857.2015
PMCID: PMC4978790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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