Article

Somatic HCN channels augment and speed up GABAergic basket cell input-output function in human neocortex

2021-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Neurons in the mammalian brain exhibit evolution-driven species-specific differences in their functional properties. Therefore, understanding the human brain requires unraveling the human neuron “uniqueness” and how it contributes to the operation of specific neuronal circuits. We show here that a highly abundant type of inhibitory neurons in the neocortex, GABAergic parvalbumin-expressing baske...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f352d29-1ed1-57c6-9007-d9da2b5eb1f4
DOI: 10.1101/2021.06.09.447671

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic HCN channels augment and speed up GABAergic basket cell input-output function in human neocortexDOI 10.1101/2021.06.09.447671Read

The paradoxical effects of K <sup>+</sup> channel gain-of-function are mediated by GABAergic neuron hypoexcitability and hyperconnectivitySemantic proximity Read

Modeling reveals human-rodent differences in h-current kinetics influencing resonance in cortical layer 5 neuronsSemantic proximity Read

Hyperpolarization-activated cation channels shape the spiking frequency preference of human cortical layer 5 pyramidal neuronsSemantic proximity Read

Comparative specialization of intrinsic cardiac neurons in humans, mice, and pigsSemantic proximity Read

Heterozygous expression of a <i>Kcnt1</i> gain-of-function variant has differential effects on SST- and PV-expressing cortical GABAergic neuronsSemantic proximity Read

Transcriptome-Inspired Spiking Simulations Uncover Human-Specific Prefrontal Dynamics and Provide a Mechanistic Platform for Species-Appropriate Disease ModelingSemantic proximity Read

Parvalbumin Interneuron Impairment Leads to Synaptic Transmission Deficits and Seizures in <i>SCN8A</i> Epileptic EncephalopathySemantic proximity Read

Cellular and Synaptic Diversity of Layer 2-3 Pyramidal Neurons in Human IndividualsSemantic proximity Read

Electrophysiological heterogeneity of fast-spiking interneurons: chandelier versus basket cells.Semantic proximity Read

Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell typeSemantic proximity Read

Human outperform mouse Purkinje cells in dendritic complexity and computational capacitySemantic proximity Read

h-channels contribute to divergent electrophysiological properties of supragranular pyramidal neurons in human versus mouse cerebral cortexSemantic proximity Read