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Article

Scn2a sodium channel mutation results in hyperexcitability in the hippocampus in vitro.

Epilepsia - 1 Mar 2008

Kile Kara Buehrer, Tian Nan, Durand Dominique M

Abstract excerpt

PURPOSE: To investigate in vitro, the cellular network activity of the hippocampus in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene. METHODS: Extacellular recordings were obtained from CA1 and CA3 pyramidal neurons in hippocampal slices prepared from Q54 transgenic and nontransgenic littermates (WT) under physiologic conditions as well as during...

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Identifiers

PMID: 18031550
DOI: 10.1111/j.1528-1167.2007.01413.x
PMCID: PMC2720056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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