Article
Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes.
Neuron - 18 Sept 2013
Del Pino Isabel, García-Frigola Cristina, Dehorter Nathalie, Brotons-Mas Jorge R, Alvarez-Salvado Efrén, Martínez de Lagrán María, Ciceri Gabriele, Gabaldón María Victoria, Moratal David, Dierssen Mara, Canals Santiago, Marín Oscar, Rico Beatriz
Abstract excerpt
Genetic variation in neuregulin and its ErbB4 receptor has been linked to schizophrenia, although little is known about how they contribute to the disease process. Here, we have examined conditional Erbb4 mouse mutants to study how disruption of specific inhibitory circuits in the cerebral cortex may cause large-scale functional deficits. We found that deletion of ErbB4 from the two main classes of fast-spiking...
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