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Article

GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.

Translational psychiatry - 17 Jul 2012

Gandal M J, Sisti J, Klook K, Ortinski P I, Leitman V, Liang Y, Thieu T, Anderson R, Pierce R C, Jonak G, Gur R E, Carlson G, Siegel S J

Abstract excerpt

Reduced N-methyl-D-aspartate-receptor (NMDAR) signaling has been associated with schizophrenia, autism and intellectual disability. NMDAR-hypofunction is thought to contribute to social, cognitive and gamma (30-80 Hz) oscillatory abnormalities, phenotypes common to these disorders. However, circuit-level mechanisms underlying such deficits remain unclear. This study investigated the relationship between gamma...

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Identifiers

PMID: 22806213
DOI: 10.1038/tp.2012.69
PMCID: PMC3410621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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