Multi-modal characterization and simulation of human epileptic circuitry

Abstract excerpt

Temporal lobe epilepsy is the fourth most common neurological disorder with about 40% of patients not responding to pharmacological treatment. Increased cellular loss in the hippocampus is linked to disease severity and pathological phenotypes such as heightened seizure propensity. While the hippocampus is the target of therapeutic interventions such as temporal lobe resection, the impact of the disease at the cel...

Topics

Open a Topic to create a Post that cites this publication.

• Epilepsy
• Forecasting
• Ion Channel Gating
• Ion Channels
• Models, Neurological
• Models, Statistical
• Neural Networks, Computer
• Patch-Clamp Techniques

Identifiers and source

Literature Corpus work

0c9a7d69-4293-58ba-8b61-e4041c46dccb

DOI

10.1101/2020.04.24.060178