Article
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.
Molecular and cellular biology - 1 Nov 2005
Arimura Nariko, Ménager Céline, Kawano Yoji, Yoshimura Takeshi, Kawabata Saeko, Hattori Atsushi, Fukata Yuko, Amano Mutsuki, Goshima Yoshio, Inagaki Masaki, Morone Nobuhiro, Usukura Jiro, Kaibuchi Kozo
Abstract excerpt
Collapsin response mediator protein 2 (CRMP-2) enhances the advance of growth cones by regulating microtubule assembly and Numb-mediated endocytosis. We previously showed that Rho kinase phosphorylates CRMP-2 during growth cone collapse; however, the roles of phosphorylated CRMP-2 in growth cone collapse remain to be clarified. Here, we report that CRMP-2 phosphorylation by Rho kinase cancels the binding activity...
Topics
- Animals
- Axons
- Cell Line
- Cell Proliferation
- Chick Embryo
- Chlorocebus aethiops
- DNA, Complementary
- Dimerization
- Drosophila Proteins
- Endocytosis