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Article

CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.

Molecular and cellular biology - 1 Nov 2005

Kawano Yoji, Yoshimura Takeshi, Tsuboi Daisuke, Kawabata Saeko, Kaneko-Kawano Takako, Shirataki Hiromichi, Takenawa Tadaomi, Kaibuchi Kozo

Abstract excerpt

A neuron has two types of highly polarized cell processes, the single axon and multiple dendrites. One of the fundamental questions of neurobiology is how neurons acquire such specific and polarized morphologies. During neuronal development, various actin-binding proteins regulate dynamics of actin cytoskeleton in the growth cones of developing axons. The regulation of actin cytoskeleton in the growth cones is...

Topics

Actins
Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
Axons
Caenorhabditis elegans
Cells, Cultured
Chromatography, Affinity
Cytoskeleton
DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dendrites

Glutathione Transferase

Hippocampus

Humans

Immunoprecipitation

Insecta

Intercellular Signaling Peptides and Proteins

Kinesins

Source

Open in PubMed Open full text

Identifiers

PMID: 16260607
DOI: 10.1128/MCB.25.22.9920-9935.2005
PMCID: PMC1280248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.PMID 16260607Read ↗

Rac1 regulates neuronal polarization through the WAVE complex.Semantic proximity Read ↗

CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.Semantic proximity Read ↗

Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.Semantic proximity Read ↗

The Arp2/3 activators WAVE and WASP have distinct genetic interactions with Rac GTPases in Caenorhabditis elegans axon guidance.Semantic proximity Read ↗

Rho and Ras GTPases in axon growth, guidance, and branching.Semantic proximity Read ↗

CRMP-2 induces axons in cultured hippocampal neurons.Semantic proximity Read ↗

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.Semantic proximity Read ↗

RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC.Semantic proximity Read ↗

CRMP5 interacts with tubulin to inhibit neurite outgrowth, thereby modulating the function of CRMP2.Semantic proximity Read ↗

Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity.Semantic proximity Read ↗

WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.Semantic proximity Read ↗

The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal β-actin mRNA translocation in spinal motor neuronsSemantic proximity Read ↗

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