Article
Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth.
PLoS biology - 1 Oct 2009
Davis David A, Wilson Meredith H, Giraud Jodel, Xie Zhigang, Tseng Huang-Chun, England Cheryl, Herscovitz Haya, Tsai Li-Huei, Delalle Ivana
Abstract excerpt
Capping protein (CP) is a heterodimer that regulates actin assembly by binding to the barbed end of F-actin. In cultured nonneuronal cells, each CP subunit plays a critical role in the organization and dynamics of lamellipodia and filopodia. Mutations in either alpha or beta CP subunit result in retinal degeneration in Drosophila. However, the function of CP subunits in mammalian neurons remains unclear. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.