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Article

Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.

Cellular signalling - 1 Dec 2009

Chae Young Chan, Lee Sukmook, Heo Kyun, Ha Sang Hoon, Jung Yonwoo, Kim Jong Hyun, Ihara Yasuo, Suh Pann-Ghill, Ryu Sung Ho

Abstract excerpt

Collapsin response mediator protein-2 (CRMP-2) plays a key role in axonal development by regulating microtubule dynamics. However, the molecular mechanisms underlying this function have not been clearly elucidated. In this study, we demonstrated that hCRMP-2, specifically amino acid residues 480-509, is essential for stimulating tubulin GTPase activity. We also found that the GTPase-activating protein (GAP)...

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Identifiers

PMID: 19666111
DOI: 10.1016/j.cellsig.2009.07.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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