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Article

CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.

Nature cell biology - 1 Sept 2003

Nishimura Takashi, Fukata Yuko, Kato Katsuhiro, Yamaguchi Tomoya, Matsuura Yoshiharu, Kamiguchi Hiroyuki, Kaibuchi Kozo

Abstract excerpt

Axon growth during neural development is highly dependent on both cytoskeletal re-organization and polarized membrane trafficking. Previously, we demonstrated that collapsin response mediator protein-2 (CRMP-2) is critical for specifying axon/dendrite fate and axon growth in cultured hippocampal neurons, possibly by interacting with tubulin heterodimers and promoting microtubule assembly. Here, we identify Numb...

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Identifiers

PMID: 12942088
DOI: 10.1038/ncb1039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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