CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.

doi:10.1038/ncb1039

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.

Nature cell biology - 1 Sept 2003

Nishimura Takashi, Fukata Yuko, Kato Katsuhiro, Yamaguchi Tomoya, Matsuura Yoshiharu, Kamiguchi Hiroyuki, Kaibuchi Kozo

Abstract excerpt

Axon growth during neural development is highly dependent on both cytoskeletal re-organization and polarized membrane trafficking. Previously, we demonstrated that collapsin response mediator protein-2 (CRMP-2) is critical for specifying axon/dendrite fate and axon growth in cultured hippocampal neurons, possibly by interacting with tubulin heterodimers and promoting microtubule assembly. Here, we identify Numb...

Topics

Animals
Cell Differentiation
Cell Polarity
Cells, Cultured
Central Nervous System
Endocytosis
Fetus
Growth Cones
Hippocampus
Intercellular Signaling Peptides and Proteins
Membrane Proteins
Microtubules
Mutation
Nerve Tissue Proteins
Neural Cell Adhesion Molecule L1
Protein Transport
RNA Interference
Rats

Source

Open in PubMed

Identifiers

PMID: 12942088
DOI: 10.1038/ncb1039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics