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Article

Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.

FEBS letters - 2 Nov 2012

Brittain Joel M, Wang Yuying, Eruvwetere Omotore, Khanna Rajesh

Abstract excerpt

The axon/dendrite specification collapsin response mediator protein-2 (CRMP-2) bidirectionally regulates N-type voltage-gated Ca(2+) channels (CaV2.2). But how cyclin dependent kinase 5 (Cdk5)-mediated phosphorylation of CRMP-2 affects its interaction/regulation with CaV2.2 is unknown. CRMP-2-mediated enhancement of currents via CaV2.2 was not observed with a Cdk5 phospho-null CRMP-2-S522A mutant or in cells...

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Identifiers

PMID: 23022559
DOI: 10.1016/j.febslet.2012.09.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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