Article
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.
Nature cell biology - 1 Aug 2002
Fukata Yuko, Itoh Tomohiko J, Kimura Toshihide, Ménager Céline, Nishimura Takashi, Shiromizu Takashi, Watanabe Hiroyasu, Inagaki Naoyuki, Iwamatsu Akihiro, Hotani Hirokazu, Kaibuchi Kozo
Abstract excerpt
Regulated increase in the formation of microtubule arrays is thought to be important for axonal growth. Collapsin response mediator protein-2 (CRMP-2) is a mammalian homologue of UNC-33, mutations in which result in abnormal axon termination. We recently demonstrated that CRMP-2 is critical for axonal differentiation. Here, we identify two activities of CRMP-2: tubulin-heterodimer binding and the promotion of...
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