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Article

Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.

The Journal of biological chemistry - 2 Oct 2009

Uchida Yutaka, Ohshima Toshio, Yamashita Naoya, Ogawara Miyuki, Sasaki Yukio, Nakamura Fumio, Goshima Yoshio

Abstract excerpt

Collapsin response mediator protein 2 (CRMP2) is an intracellular protein that mediates signaling of Semaphorin3A (Sema3A), a repulsive axon guidance molecule. Fyn, a Src-type tyrosine kinase, is involved in the Sema3A signaling. However, the relationship between CRMP2 and Fyn in this signaling pathway is still unknown. In our research, we demonstrated that Fyn phosphorylated CRMP2 at Tyr(32) residues in HEK293T...

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PMID: 19652227
DOI: 10.1074/jbc.M109.000240
PMCID: PMC2785668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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