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Article

Stable Suppression of Tumorigenicity by Pin1-Targeted RNA Interference in Prostate Cancer

15 Oct 2005

Abstract excerpt

PURPOSE: The peptidyl-prolyl isomrase Pin1 plays a catalytic role in oncogenesis in solid cancers, including prostate cancer. In the present study, we sought to determine the potential of Pin1-targeted gene silencing in inhibiting cellular growth and tumorigenicity in prostate cancer. EXPERIMENTAL DESIGN: A retrovirus-mediated RNA interference targeting Pin1 was expressed in PC3 and LNCaP cells, and cell growth...

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PMID: 16243827
DOI: 10.1158/1078-0432.ccr-05-0457

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