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Article

Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and Significance

31 Mar 2020

Abstract excerpt

isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif and, subsequently, induces the conformational change of its substrates. Mounting evidence has demonstrated that Pin1 is widely overexpressed and/or overactivated in cancer, exerting a critical influence on tumor initiation and progression via regulation of the biological activity, protein degradation, or nucleus-cytoplasmic distribution...

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PMID: 32296699
DOI: 10.3389/fcell.2020.00168

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