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The role of the master cancer regulator Pin1 in the development and treatment of cancer

30 Apr 2024

Abstract excerpt

This review examines the complex role of Pin1 in the development and treatment of cancer. Pin1 is the only peptidyl-prolyl isomerase (PPIase) that can recognize and isomerize phosphorylated Ser/Thr-Pro peptide bonds. Pin1 catalyzes a structural change in phosphorylated Ser/Thr-Pro motifs that can modulate protein function and thereby impact cell cycle regulation and tumorigenesis. The molecular mechanisms by...

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PMID: 38745861
DOI: 10.3389/fcell.2024.1343938

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