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Article

siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer.

PloS one - 1 Jan 2011

Bee Alix, Brewer Daniel, Beesley Carol, Dodson Andrew, Forootan Shiva, Dickinson Timothy, Gerard Patricia, Lane Brian, Yao Sheng, Cooper Colin S, Djamgoz Mustafa B A, Gosden Christine M, Ke Youqiang, Foster Christopher S

Abstract excerpt

We provide novel functional data that posttranscriptional silencing of gene RPL19 using RNAi not only abrogates the malignant phenotype of PC-3M prostate cancer cells but is selective with respect to transcription and translation of other genes. Reducing RPL19 transcription modulates a subset of genes, evidenced by gene expression array analysis and Western blotting, but does not compromise cell proliferation or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21799931
DOI: 10.1371/journal.pone.0022672
PMCID: PMC3142177

Genes

RPL19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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