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Article

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003

Majumder Pradip K, Yeh Jen Jen, George Daniel J, Febbo Phillip G, Kum Jennifer, Xue Qi, Bikoff Rachel, Ma Hongfeng, Kantoff Philip W, Golub Todd R, Loda Massimo, Sellers William R

Abstract excerpt

To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity was generated in transgenic mice (MPAKT mice). Akt expression led to p70S6K activation, prostatic intraepithelial neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral prostate revealed similarities to human cancer and an...

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Identifiers

PMID: 12799464
DOI: 10.1073/pnas.1232229100
PMCID: PMC164675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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