Article

PUM1 represses CDKN1B translation and contributes to prostate cancer progression

2021-05-30

Abstract excerpt

Posttranscriptional regulation of cancer gene expression programs plays a vital role in carcinogenesis; identifying the critical regulators of tumorigenesis and their molecular targets may provide novel strategies for cancer diagnosis and therapeutics. Highly conserved RNA binding protein PUM1 regulates mouse growth and cell proliferation, propelling us to examine its role in cancer. We found human PUM1 is highly...

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Literature Corpus work: 20f5cdfc-6f12-5b5f-a77a-0f95d5336a5a
DOI: 10.1101/2021.05.27.21257930

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