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Article

Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction.

Molecular and cellular biology - 1 Feb 2006

Chen Shao-Yong, Wulf Gerburg, Zhou Xiao Zhen, Rubin Mark A, Lu Kun Ping, Balk Steven P

Abstract excerpt

Androgen receptor (AR) interacts with beta-catenin and can suppress its coactivation of T cell factor 4 (Tcf4) in prostate cancer (PCa) cells. Pin1 is a peptidyl-prolyl cis/trans isomerase that stabilizes beta-catenin by inhibiting its binding to the adenomatous polyposis coli gene product and su...

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Source

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Identifiers

PMID: 16428447
DOI: 10.1128/MCB.26.3.929-939.2006
PMCID: PMC1347015

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16428447-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction.PMID 16428447Read ↗

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Stable Suppression of Tumorigenicity by Pin1-Targeted RNA Interference in Prostate CancerSemantic proximity Read ↗

β-Catenin Is Required for Prostate Development and Cooperates with Pten Loss to Drive Invasive CarcinomaSemantic proximity Read ↗

Targeting Pin1 for Modulation of Cell Motility and Cancer TherapySemantic proximity Read ↗

Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.Semantic proximity Read ↗

Prevalent overexpression of prolyl isomerase Pin1 in human cancers.Semantic proximity Read ↗

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Targeting carcinogenesis: A role for the prolyl isomerase Pin1?Semantic proximity Read ↗

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