Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

9 Jun 2017

Abstract excerpt

The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is overexpressed in the majority of cancers and its activity strongly contributes to tumour initiation and progression. Inactivation of PIN1 function conversely curbs tumour growth and cancer stem cell expansion, restores chemosensitivity and blocks metastatic spread, thus providing the rationale for a therapeutic strategy based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Macrophage Migration Inhibitory Factor
Share to Peptidase Inhibition and Analysis
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28598431
DOI: 10.1038/ncomms15772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of actionPMID 28598431Read ↗

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Small molecules targeting Pin1 as potent anticancer drugsSemantic proximity Read ↗

Identification of a potent and selective covalent Pin1 inhibitorSemantic proximity Read ↗

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivoSemantic proximity Read ↗

The role of Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Pin1 inhibitors: Pitfalls, progress and cellular pharmacologySemantic proximity Read ↗

Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future DirectionsSemantic proximity Read ↗

Targeting Pin1 for Modulation of Cell Motility and Cancer TherapySemantic proximity Read ↗

Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and SignificanceSemantic proximity Read ↗

Oncogenic Hijacking of the PIN1 Signaling NetworkSemantic proximity Read ↗

The kingdom of the prolyl-isomerase Pin1: The structural and functional convergence and divergence of Pin1Semantic proximity Read ↗

A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.