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Article

PIN1 expression contributes to hepatic carcinogenesis

14 Jul 2006

Abstract excerpt

The phospho-Ser/Thr-Pro specific prolyl-isomerase PIN1 is over-expressed in more than 50% of hepatocellular carcinomas (HCCs). To investigate its potential oncogenicity, we over-expressed PIN1 in a non-transformed human liver cell line MIHA. This resulted in up-regulation of beta-catenin and cyclin D1, leading to anchorage-independent growth in soft agar and tumorigenicity in nude mice. To further validate the...

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PMID: 16841372
DOI: 10.1002/path.2024

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PIN1 expression contributes to hepatic carcinogenesisPMID 16841372Read ↗

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