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Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

31 Mar 2021

Abstract excerpt

isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell...

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PMID: 33807199
DOI: 10.3390/biomedicines9040359

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