Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer risks in first degree relatives of BRCA1 mutation carriers: effects of mutation and proband disease status.

Journal of medical genetics - 1 May 2006

Gronwald J, Huzarski T, Byrski B, Medrek K, Menkiszak J, Monteiro A N, Sun P, Lubinski J, Narod S A

Abstract excerpt

BACKGROUND: Mutations in the BRCA1 (MIM 113705) gene are found in many families with multiple cases of breast and ovarian cancer, and women with a BRCA1 mutation are at significantly higher risk of developing breast and ovarian cancer than are the general public. METHODS: We obtained blood samples and pedigree information from 3568 unselected cases of early-onset breast cancer and 609 unselected patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Founder Effect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Heterozygote

Share to Incidence

Share to Ovarian Neoplasms

Share to Pedigree

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 16227521
DOI: 10.1136/jmg.2005.036921
PMCID: PMC2564518

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer risks in first degree relatives of BRCA1 mutation carriers: effects of mutation and proband disease status.PMID 16227521Read ↗

Family History of Breast and Ovarian Cancers and BRCA1 and BRCA2 Mutations in a Population-Based Series of Early-Onset Breast CancerSemantic proximity Read ↗

Increased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

BRCA1/BRCA2 founder mutations and cancer risks: impact in the western Danish population.Semantic proximity Read ↗

Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history.Semantic proximity Read ↗

Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers.Semantic proximity Read ↗

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.Semantic proximity Read ↗

Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.Semantic proximity Read ↗

Cancer risks among first-degree relatives of women with a genetic predisposition to breast cancer.Semantic proximity Read ↗

Familial risks, early-onset breast cancer, and BRCA1 and BRCA2 germline mutations.Semantic proximity Read ↗

Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program.Semantic proximity Read ↗

Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations.Semantic proximity Read ↗

BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.