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Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers.

The oncologist - 1 Jul 2016

Streff Haley, Profato Jessica, Ye Yuanqing, Nebgen Denise, Peterson Susan K, Singletary Claire, Arun Banu K, Litton Jennifer K

Abstract excerpt

BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are associated with increased risk of breast, ovarian, and several other cancers. The purpose of the present study was to evaluate the incidence of cancer in first- and second-degree relatives of BRCA mutation carriers compared with the general population. MATERIALS AND METHODS: A total of 1,086 pedigrees of BRCA mutation carriers was obtained from a...

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Source

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Identifiers

PMID: 27306910
DOI: 10.1634/theoncologist.2015-0354
PMCID: PMC4943383

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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