Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRCA1/BRCA2 founder mutations and cancer risks: impact in the western Danish population.

Familial cancer - 1 Oct 2016

Nielsen Henriette Roed, Nilbert Mef, Petersen Janne, Ladelund Steen, Thomassen Mads, Pedersen Inge Søkilde, Hansen Thomas V O, Skytte Anne-Bine, Borg Åke, Therkildsen Christina

Abstract excerpt

Mutations in the BRCA1 and BRCA2 genes significantly contribute to hereditary breast cancer and ovarian cancer, but the phenotypic effect from different mutations is insufficiently recognized. We used a western Danish clinic-based cohort of 299 BRCA families to study the female cancer risk in mutation carriers and their untested first-degree relatives. Founder mutations were characterized and the risk of cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Denmark

Share to Founder Effect

Share to Genetics, Population

Share to Neoplasms

Share to Ovarian Neoplasms

Source

Identifiers

PMID: 26833046
DOI: 10.1007/s10689-016-9875-7

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1/BRCA2 founder mutations and cancer risks: impact in the western Danish population.PMID 26833046Read ↗

BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark.Semantic proximity Read ↗

Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population.Semantic proximity Read ↗

BRCA1 and BRCA2 mutations in Danish families with hereditary breast and/or ovarian cancer.Semantic proximity Read ↗

The role of BRCA1/2 in hereditary and familial breast and ovarian cancersSemantic proximity Read ↗

Cancer risks in first degree relatives of BRCA1 mutation carriers: effects of mutation and proband disease status.Semantic proximity Read ↗

Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations.Semantic proximity Read ↗

Founder mutations in BRCA1 and BRCA2 genes.Semantic proximity Read ↗

High prevalence of BRCA1 founder mutations in Greek breast/ovarian families.Semantic proximity Read ↗

BRCA1 and BRCA2 mutation spectrum – an update on mutation distribution in a large cancer genetics clinic in NorwaySemantic proximity Read ↗

BRCA1 and BRCA2: the genetic testing and the current management options for mutation carriers.Semantic proximity Read ↗

Prevalence, spectrum, and founder effect of BRCA1 and BRCA2 mutations in epithelial ovarian cancer from the Middle EastSemantic proximity Read ↗

BRCA1 founder mutations and beyond in the Polish population: A single-institution BRCA1/2 next-generation sequencing study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.