Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations.

doi:10.1136/jmedgenet-2013-101974

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Article

Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations.

Journal of medical genetics - 1 Feb 2014

Brohet Richard M, Velthuizen Maria E, Hogervorst Frans B L, Meijers-Heijboer Hanne E J, Seynaeve Caroline, Collée Margriet J, Verhoef Senno, Ausems Margreet G E M, Hoogerbrugge Nicoline, van Asperen Christi J, Gómez García Encarna, Menko Fred, Oosterwijk Jan C, Devilee Peter, van't Veer Laura J, van Leeuwen Flora E, Easton Douglas F, Rookus Matti A, Antoniou Antonis C

Abstract excerpt

BACKGROUND: BRCA1 or BRCA2 mutations confer increased risks of breast and ovarian cancer, but risks have been found to vary across studies and populations. METHODS: We ascertained pedigree data of 582 BRCA1 and 176 BRCA2 families and studied the variation in breast and ovarian cancer risks using a modified segregation analysis model. RESULTS: The average cumulative breast cancer risk by age 70 years was estimated...

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PMID: 24285858
DOI: 10.1136/jmedgenet-2013-101974

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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