Article
Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history.
Journal of the National Cancer Institute - 5 Feb 1997
Berry D A, Parmigiani G, Sanchez J, Schildkraut J, Winer E
Abstract excerpt
BACKGROUND: Heritable mutations of the breast cancer gene BRCA1 are rare, occurring in fewer than 1% of women in the general population, and therefore account for a small proportion of cases of breast and ovarian cancers. Nevertheless, the presence of such mutations is highly predictive of the de...
Topics
- Adult
- Age Factors
- Aged
- Bayes Theorem
- Breast Neoplasms
- Family
- Female
- Heterozygote
- Humans
- Medical History Taking
- Middle Aged
- Models, Theoretical
- Mutation
- Odds Ratio
- Ovarian Neoplasms
- Pedigree
- Prevalence
- Risk