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Article

Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history.

Journal of the National Cancer Institute - 5 Feb 1997

Berry D A, Parmigiani G, Sanchez J, Schildkraut J, Winer E

Abstract excerpt

BACKGROUND: Heritable mutations of the breast cancer gene BRCA1 are rare, occurring in fewer than 1% of women in the general population, and therefore account for a small proportion of cases of breast and ovarian cancers. Nevertheless, the presence of such mutations is highly predictive of the development of these cancers. PURPOSE: We developed and applied a mathematic model for calculating the probability that a...

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Source

Identifiers

PMID: 9017003
DOI: 10.1093/jnci/89.3.227

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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